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This makes it impractical for routine clinical use, necessitating the development of modified GLP-1 receptor agonists like semaglutide

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Sacks DA, Black MH, Li X, et al

First approved to treat type 2 diabetes, GLP-1 based drugs are now used to aid weight loss in obesity and to help lower the risk of heart failure and treat obstructive sleep apnea, a common breathing-related sleep disorder, in people with obesity