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Both trials (NCT03887455 and NCT01760005) had a overall low risk of bias [43, 53, 83, 84]

And once starting the medications, it is equally vital to have regular check ins with your provider, and complete updated information forms when re-ordering each month - rolling subscriptions and an Amazon-esque style of ordering should be red flags when it comes to weight loss medications where your statistics and experience can mean the difference between continuing usage or discontinuing the medications

Ultimately, the best medication for you should be determined by your healthcare provider, who can consider various factors to identify the best treatment for your condition

doi: 10.3389/fnut.2026.1778473 Received 31 December 2025 Revised 09 March 2026 Accepted 26 March 2026 Published 28 April 2026 Volume 13 - 2026 Edited by Huanling Lai, Guangzhou National Laboratory, China Reviewed by Jiayi Zhou, University of North Carolina at Chapel Hill, United States Mairepaiti Halimulati, The University of Texas at Austin, United States Updates Copyright 2026 Sun, Sun, Nan, Wang, Sun, Shi, Yang and Wang