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Tracking your symptoms in a food and symptom diary helps identify your personal reflux triggers and refine your approach, turning short-term discomfort into evidence for long-term success

Abbreviations BBB: Blood-brain barrier CGRP: Calcitonin gene-related peptide CM: Chronic migraine CNS: Central nervous system CSD: Cortical spreading depression DMEM: Dulbeccos modified Eagles medium FBS: Foetal bovine serum GLP-1R: Glucagon-like peptide-1 receptor IGF-1: Insulin-like growth factor-1 IS: Inflammatory soup LPS: Lipopolysaccharide NTG: Nitroglycerin PI3K: Phosphoinositide 3-kinase PKA: Protein kinase A PMSF: Phenylmethylsulfonyl fluoride RT: Room temperature TNC: Trigeminal nucleus caudalis References May A, Schulte LH (2016) Chronic migraine: risk factors, mechanisms and treatment

El diagnstico oportuno y el tratamiento adecuado son de suma importancia, ya que pueden prevenir complicaciones y favorecer la salud general de la persona

The longest studies in therapeutic dose long-term users extend for only 10 months after withdrawal