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Epithelial barrier hypothesis: effect of the external exposome on the Microbiome and epithelial barriers in allergic disease

GCL is composed of a heavy catalytic subunit (GCLC, MW ~ 73,000) and a light modifier (GCLM, MW ~ 30,000) subunit

These studies demonstrated that fasting upregulates the plasma membrane OCTN2 carnitine transporter in the liver, heart, kidneys and in rats with strong caloric restriction, additionally in skeletal muscle [111]

The biological rationale is that the body's healing program is itself coordinated, so supporting cell migration and local repair signaling together, rather than in isolation, is intended to better match how tissue actually rebuilds