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The basis of this finding is thought to be the affected cholinergic pathways in the cerebral cortex and basal forebrain in AD [109] and therefore the consequential cholinergic insufficiency adds to the cognitive damage [110]

Sebaceous Gland Anatomy and Physiology Aside from the free sebaceous glands on the vermilion lips (Fordyce granules), eyelids (meibomian glands), areolae (Montgomery tubercles), and labia minora and prepuce (Tyson glands), the duct of the sebaceous gland connects to the infundibulum of a hair follicle.[1] These glands are highly concentrated behind the ear and on the face, upper chest, and back, which happens to be the same distribution as acne vulgaris.[2] The major cells comprising sebaceous glands are sebocytes, and these cells disintegrate and release sebum via holocrine secretion

A separate 2025 narrative review flagged theoretical concerns about pathologic new blood vessel formation relevant for anyone with cancer history or proliferative conditions

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