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Within islet cells, GLP-1RAs activate adenylate cyclase to increase the production of intracellular cyclic adenosine monophosphate (cAMP) and to start the subsequent signaling cascade (Figure 1) [28]

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Many growth factors show similar patterns where optimal stimulation occurs within a narrow concentration window, and excess amounts trigger inhibitory feedback

Treasure Island (FL): StatPearls Publishing Shaka H, Salim M, DeHart L, El-Amir Z, Wani F, Kichloo A (2022) A decade of hospitalizations for hyperthyroidism in the US