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TNF- can induce the proliferation of fibroblast-like synoviocytes (FLS) and synovial cells by activating nuclear factor kappa-B (NF-B) and extracellular regulated protein kinases (Erk)-1/2-E26 transformation-specific (ETS)-1 signaling pathway, respectively ( + T cells ( via GM-CSFR signaling ( Table 1 shows, many agents aiming at different cytokine targets have been developed and applied in practice, such as TNF inhibitors, IL-6 inhibitors, IL-1 inhibitors, IL-15 inhibitors, IL-17 inhibitors, and so on