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150 Chronic fructose intake leads to gut flora dysbiosis, tight junction protein downregulation, secretory cell depletion, and elevated pro-inflammatory cytokines, thereby disrupting the gut barrier and triggering endotoxemia-mediated liver inflammation and fibrosis

Sinclair was sitting at his desk at Harvard one day in 2010 when a colleague called to offer his heartfelt sympathies: Pfizer scientists had just released a paper essentially saying that Sinclairs work on sirtuins was bunk

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