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140 It has also been reported that high mechanical loading not only promotes the secretion of inflammatory and pain-related factors of IVD cells, such as TNF-, IL-6, IL-8, IL-17, IFN-, monocyte chemoattractant protein 1 (MCP-1), and NGF, but also upregulates TLR2 and TLR4 expression, indicating that mechanical stress may play important roles in inducing and maintaining discogenic LBP

In skeletal muscle, promotes stem cell proliferation, regeneration, and muscle fiber hypertrophy post-injury 1

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Hormonal Effects on Temperature Regulation Hormones play a significant role in regulating body temperature