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GI Adverse Effects of Glucagon-Like Peptide-1 Receptor Agonists These agents are commonly used therapies for managing diabetes and obesity, but gastrointestinal adverse effects such as nausea, vomiting, diarrhea, and constipation frequently limit therapy

In animal experiments, GLP-1RAs induce frequent vomiting, whereas GIP receptor agonists do not

Key brain regions with GLP-1 receptor expression include: Hypothalamus : Multiple hypothalamic nuclei express GLP-1 receptors, particularly the arcuate nucleus (ARC), paraventricular nucleus (PVN), and ventromedial hypothalamus (VMH)