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The effective blood-brain barrier mechanism impeding the transport of monoamines has been attributed to both the presence of tight junctions cementing adjacent endothelial cells of the cerebral capillary walls, along with high concentrations of dopa decarboxylase and monoamine oxidase (MAO) in the cerebral capillary endothelium (Bertler et al, 1966

Subsequently, in the second reaction catalyzed by the enzyme glutathione synthetase (GS), GSH is produced from -glutamylcysteine and glycine [36]

van Heck, J

Effects of anti-inflammatory drugs on convulsant activity of quinolones: a comparative study of drug interaction between quinolones and anti-inflammatory drugs