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Firstly, the spontaneous reporting system is affected by limitations within the FAERS database, including duplicate reports, reporting accuracy and quality, incomplete or insufficient details regarding drug administration (such as site, route, dose and timing), and the lack of important patient characteristics (such as medical history and comorbidities)

Constipation becomes the dominant side effect for many patients after nausea subsides

Scientists have identified it as one of the most important molecules for human health

402 About ten years ago, vemurafenib and dabrafenib had been approved by FDA for the treatment of advanced melanoma harboring BRAF mutations