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The augmentation of mitochondrial functionality, alterations in intracellular GSH concentrations, and elevation of c-glutamyl transpeptidase activity collectively facilitated the physiological amplification of androgens, leading to the potentiation of OS in LNCaP human prostate cancer cells that are responsive to androgens (81)

3.2.3 JAK/STAT signaling pathway In PC, abnormal and prolonged Janus kinase/signal transducer and activator of transcription (JAK/STAT) activation is associated with tumor development, progression and lineage plasticity

For instance, aflatoxins, produced by Aspergillus molds, are known to be linked to liver damage