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Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents

Yamamoto H, Kishi T, Lee CE, Choi BJ, Fang H, Hollenberg AN, Drucker DJ, Elmquist JK: Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites

In these animals, both meal size and food intake during refeeding after fasting were increased, and postprandial insulin secretion was reduced, leading to elevated postprandial blood glucose levels [51]

If SGLT2i are used in those with eGFR 8%, then the addition of these agents is less likely to cause hypoglycemia but the patient should be counselled about the potential for hypoglycemia