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16 Meanwhile, prior work has demonstrated that individual responses to statins, both in terms of on-target low-density lipoprotein (LDL) lowering and in terms of off-target insulin resistance, can be explained by baseline variation in the microbiome

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However, with the exception of R310 5 .40 , where it forms a more persistent hydrogen bond, these interactions are again very transient and there are no interactions with TM3