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Prior treatment with CBD then treatment with cisplatin significantly decreased cell viability more than cisplatin-treated cells without prior treatment with CBD (Kosgodage et al

Nevertheless, the main components of cigarette smoking has inflammatory-regulatory properties, for instance, Heme oxygenase-1 (HO-1) and carbon monoxide (CO) play a role in modulating cytokine expression and macrophage bactericidal activity, regulating intestinal homeostasis and mucosal immune responses to the enteric microbiota [155, 156], both of which were involved in the possible pathological process in UC